Emerging evidence suggests that exercise-induced fatigue not only compromises athletic performance but also negatively affects nervous system function. However, effective strategies to prevent or mitigate its adverse neurological consequences remain limited. Using a rat exhaustive exercise training paradigm, this study aims to determine whether intranasal methylene blue (MB) can mitigate neuronal damage ...

ABSTRACTBackground: Cutaneous melanoma is a highly invasive tumor. It enhances metastasis and resistance to immunotherapy via immunosuppressive mechanisms. Understanding RNA-binding proteins (RBPs) in melanomas immune alterations is limited. This study explores immune-regulatory RBPs in metastasis and clarifies RNASEs role in immune regulation.Methods: Utilizing the bulk RNA-seq datasets of melanoma,...

AbstractBackground: Psoriasis is an immune-mediated skin disease where Th17 cell differentiation and IL-17 secretion play critical roles. This study investigates key exosomal ncRNAs regulating the Th17/IL-17 axis in psoriasis and their mechanisms.Methods: We integrated bulk RNA sequencing datasets from the GEO database to construct and evaluate exosome-related patterns. Subsequently, exosome-related ...

食源性致病菌 ssDNA 适配体的筛选及应用进展张明单链DNA(single-stranded DNA,ssDNA)适配体是通过体外配体指数富集系统进化筛选获得的较短的单链脱氧核糖核苷酸序列。它们能够通过构象变化实现与靶标高亲和力和特异性结合，具有制备简单、成本低、稳定性高、易于修饰和免疫原性低等优点，因此被称为“化学抗体”。ssDNA适配体已在食品安全检测领域显示出巨大潜力。作者综述了基于细胞指数富集配体系统进化（systematic evolution of ...

ABSTRACTIPurpose: Diabetic cardiomyopathy (DCM) is a major complication of type 2 diabetes mellitus(T2DM), but its effective prevention and treatment are still limited. We investigated the effects of GYY4137, a slow-releasing hydrogen sulfide donor, and its downstream mediator forkhead box protein 01 (FOX01) on T2DM-associated DCM. Methods: In vivo, T2DM mice were induced by a high-fat diet coupled ...

Background and study aims: The integration of traditional Chinese medicine and Western medicine holds promise for the treatment of gastrointestinal disorders, which are influenced by intestinal microbiota and metabolites.This study reports a possible mechanism for the combination of Simo Decoction and Golden Bifid in functional dyspepsia (FD) by regulating intestinal microbiota and short-chain fatty ...

The rapid spread of COVID-19 has resulted in a large number of infections and significant economic impact on countries worldwide, and COVID-19 testing is one of the important methods to identify infected individuals. The previous studies have indicated that with improved COVID-19 testing capabilities, more confirmed cases can be detected. Therefore, how to accurately forecast the COVID-19 testing capabilities ...

ABSTRACTBACKGROUND: Clostridium botulinum and Clostridium perfringens, 2 major foodborne pathogenic fusobacteria, have a variety of virulent protein types with nervous and enterotoxic pathogenic potential, respectively.OBJECTIVE: The relationship between the molecular evolution of the 2 Clo stridium genomes and virulence proteins was studied via a bioinformatics prediction method. The genetic stability,...

黄泽娜Background: Diabetic nephropathy (DN) is one of the primary causes of end-stage renal disease, yet effective therapeutic targets remain elusive. This study aims to identify novel diagnostic biomarkers and potential therapeutic candidates for DN.Methods: Differentially expressed genes (DEGs) in GSE96804 and GSE142025 were identified and functional enrichment analysis was performed. Diagnostic ...

Identification of steroid-induced osteonecrosis of the femoral head biomarkers based on immunization and animal experiments高鹏飞AbstractBackground Steroid-induced osteonecrosis of femoral head (SONFH) is a severe health risk, and this study aims to identify immune-related biomarkers and pathways associated with the disease through bioinformatics analysis and animal experiments.Method Using SONFH-related ...